Omnivorous, feeding on grains, cereals, mushrooms, fruits, vegetables, waste, insects and meat.
In nature, 1 to 2 years and up to 6 years in captivity.
Mating can occurs throughout the year. The female produces 5 to 15 litters of 5 to 12 young per year, which are altricial. Gestation lasts for 18 to 21 days. The house mouse becomes sexually mature between the ages of 5-6 weeks.
The house mouse has many mammal and bird predators.