Like other mustelids, American minks are strictly carnivorous. Their high metabolic rate requires that they eat 10% of their body weight every day in small animals, fish, birds, insects, amphibians and reptiles. They hunt both on land and underwater.
In nature, 3 to 6 years and around 10 years in captivity.
Breeding takes place in February or March. The gestation period lasts on average 51 days, with a short delayed implantation period and about 30 days of embryonic development. The young are born in April or May in litters consisting of 3 to 4 babies. Weaning occurs after 5 to 6 weeks.
Humans preys on minks for their fur. Their other predators are many: dogs, red foxes, coyotes, lynx, great horned owls and otters.